FIGURE

Fig. 6

ID

ZDB-FIG-220509-16

Publication

Amanda et al., 2022 - IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

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Fig. 6

Downregulation of p53 targets and <italic>id3</italic>.

A Heatmap showing the significantly downregulated genes from one-to-one differential gene analysis of scRNA-seq data between DN populations of different tumor stages. B–D Violin plots showing the expression of btg1, btg2 and stk17al (B), mcl1a (C), id3 (D) in DN cell populations across tumor stages analyzed by scRNA-seq (total cell number after merging of biologically independent samples: Control n = 557 cells; P_IRF4n = 2,222 cells; E_IRF4n = 3,365; L_IRF4n = 15,280 cells; L_MTn = 28,205 cells). See Fig. 5C legend for the details of violin plots. Source data are provided as a Source Data file.

Expression Data

Genes:	btg1 btg2 id3 mcl1a stk17al
Fish:	ns106Tg/ns106Tg tp53^zdf1/+; ns106Tg/ns106Tg
Anatomical Term:	pro-T cell neoplasm
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ns106Tg/ns106Tg tp53^zdf1/+; ns106Tg/ns106Tg
Observed In:	pro-T cell negative regulation of signal transduction by p53 class mediator pro-T cell neoplasm
Stage:	Adult

Phenotype Detail

Acknowledgments

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