FIGURE

Fig. 2

ID

ZDB-FIG-220509-12

Publication

Amanda et al., 2022 - IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

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Fig. 2

<italic>IRF4</italic>-driven zebrafish tumors recapitulate invasive human T-cell lymphoma.

A Histopathological examination of H&E-stained tissue sections of representative samples from control Tg(lck:mCherry;p53^wt/wt) (n = 8), Tg(lck:IRF4;p53^wt/wt) (n = 8) and Tg(lck:IRF4;p53^wt/mut) (n = 4) zebrafish at 5 or 8 months. Similar findings were observed in multiple independent animals as shown for each sample. Tumor cells are indicated by white or black arrowheads. Scale bar = 100 μm. B Transverse sections of representative samples from Tg(lck:mCherry;p53^wt/wt) (n = 8) and Tg(lck:IRF4;p53^wt/wt) (n = 8). F, fin; G, gill; M, muscle; S, skin; and SC, spinal cord. Similar findings were observed in multiple independent animals as shown for each sample. Scale bar = 2 mm. C High magnification of skin lesions from Tg(lck:IRF4;p53^wt/wt) fish. Scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ns106Tg/ns106Tg tp53^zdf1/+; ns106Tg/ns106Tg
Observed In:	gill neoplasm integument neoplasm kidney neoplasm skeletal muscle neoplasm spinal cord neoplasm
Stage:	Adult

Phenotype Detail

Acknowledgments

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