FIGURE

FIGURE 4

ID

ZDB-FIG-220406-4

Publication

Zheng et al., 2022 - Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model

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FIGURE 4

Kif15 knocking down leads to abnormal posterior lateral line (PLL) development, which is represented by a decrease in the number of neuromasts (NMs). (A–D) Kif15 inhibition induces the reduction of NMs in zebrafish PLL, while co-injection of Kif15 mRNA with Kif15-MO successfully rescues the decreased number of NMs compared to the Con-MO-treated controls. The PLL NMs are indicated by white arrowheads. Scale bar is 200 μm. (E) Statistical analysis in quantification of PLL NMs in Con-MO-injected controls, Kif15-MO-injected embryos, and Kif15-MO + Kif15 mRNA group (n = 50 in the three groups). Data are recorded as mean ± SEM. *p < 0.05, ****p < 0.0001 vs. Con-MO group; ^####p < 0.0001 vs. Kif15-MO group. (F) Simple and intuitive schematic diagram of changes in PLL development after Kif15 knockdown by MO.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf106Tg + MO2-kif15
Knockdown Reagent:	MO2-kif15
Observed In:	posterior lateral line development posterior lateral line neuromast
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.