FIGURE

Fig. 4

ID

ZDB-FIG-220304-48

Publication

Aman et al., 2021 - Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development

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Fig. 4

Dio2 is necessary for normal squamation pattern. (A) Loss of Dio2 function led to more numerous, smaller scales; similar to fish lacking thyroid glands. Visualized in sp7:EGFP transgenics (n = 7, each genotype). (B) Similar to thyroid-ablated tg:Venus-NTR hypoTH fish, dio2 mutants began developing scales later, at a significantly larger standard length (SL; t12 = 20.11, p < 0.0001; n = 7 each genotype). (C) Like thyroid-ablated hypoTH fish, change in timing and size at initiation of scale development was associated with an increased number of adult scales (t12 = 19.84, p < 0.0001). Bars in plots indicate means ± 95% CI. Scale bars, (A) 1 mm.

Expression Data

Gene:	EGFP
Fish:	dio2^vp42rc1/+; b1212Tg dio2^{vp42rc1/vp42rc1}; b1212Tg
Anatomical Terms:	scale scale primordium
Stage Range:	Days 21-29 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dio2^vp42rc1/+; b1212Tg dio2^{vp42rc1/vp42rc1}; b1212Tg
Observed In:	scale scale negative regulation of dermatome development scale regulation of dermatome development scale primordium
Stage Range:	Days 21-29 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 477, Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M., Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development, 205-218, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.