ZFIN Image: Aman et al., 2021, Fig. 4

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Figure Caption

Fig. 4 Dio2 is necessary for normal squamation pattern. (A) Loss of Dio2 function led to more numerous, smaller scales; similar to fish lacking thyroid glands. Visualized in sp7:EGFP transgenics (n = 7, each genotype). (B) Similar to thyroid-ablated tg:Venus-NTR hypoTH fish, dio2 mutants began developing scales later, at a significantly larger standard length (SL; t12 = 20.11, p < 0.0001; n = 7 each genotype). (C) Like thyroid-ablated hypoTH fish, change in timing and size at initiation of scale development was associated with an increased number of adult scales (t12 = 19.84, p < 0.0001). Bars in plots indicate means ± 95% CI. Scale bars, (A) 1 mm.

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Acknowledgments

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Reprinted from Developmental Biology, 477, Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M., Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development, 205-218, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.