FIGURE

Fig. 3

ID

ZDB-FIG-220304-47

Publication

Aman et al., 2021 - Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development

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Fig. 3

Normal patterning of squamation does not depend on body growth rate. (A) Mutants homozygous for a presumptive null allele of gh1 developed squamation similar to heterozygous siblings, visualized in sp7:EGFP transgenics in individual animals over time (n = 8 each genotype). (B) gh1 mutants grew more slowly than heterozygous siblings or hypoTH fish. (C) gh1 mutants added scales more slowly than heterozygous controls (n = 8, each condition), but more quickly than hypoTH animals (D). gh1 mutants had less body surface area expansion than heterozygous siblings (n = 8), or hypoTH individuals. (E) Scale surface area (SA), as a proportion total skin SA over time shows that gh1 mutants have a specific defect in allometric scale growth, despite normal squamation pattern. hypoTH data in C and D is replotted from Fig. 1 for reference. Scale bars, (A) 1 mm.

Expression Data

Gene:	EGFP
Fish:	gh1^wp22e1/+; b1212Tg gh1^{wp22e1/wp22e1}; b1212Tg
Anatomical Terms:	scale scale primordium
Stage Range:	Days 21-29 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gh1^wp22e1/+; b1212Tg gh1^{wp22e1/wp22e1}; b1212Tg
Observed In:	larval development scale scale primordium
Stage Range:	Days 21-29 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 477, Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M., Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development, 205-218, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.