FIGURE

Fig. 4

ID

ZDB-FIG-210804-17

Publication

Fang et al., 2021 - Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

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Fig. 4

Zebrafish adult <italic>asxl1</italic> mutants progress to CMML-like or AML-like phenotypes.

A May–Grünwald–Giemsa staining of peripheral blood (PB) and whole kidney marrow (KM) cells presentative five fish with CMML-like and two fish with AML-like phenotypes (scale bar, 20 μm; black boxes show enlarged details of macrophages and myeloid progenitors; red arrows, macrophages; yellow arrows, myeloid progenitors). B Hematoxylin and eosin staining of paraffin-embedded sections of liver from representative asxl1^+/+ (a, b) and asxl1^−/− (c–f) (scale bar, 40 μm; black box, macrophage infiltration; green arrow, vacuolated cytoplasm; red arrow, gaps; yellow arrow, fibrosis) (color figure online).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	asxl1^sm19/sm19 (AB)
Observed In:	blood monocyte head kidney monocyte hepatocyte vacuole liver liver macrophage
Stage:	Adult

Phenotype Detail

Acknowledgments

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