FIGURE

Fig. 2

ID

ZDB-FIG-210412-7

Publication

Zhao et al., 2021 - MicroRNA-1 affects the development of the neural crest and craniofacial skeleton via the mitochondrial apoptosis pathway

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Fig. 2

MicroRNA-1 knockout affects neural crest cell apoptosis during the migration and differentiation periods of embryonic development. In situ hybridization of zebrafish at 24 hpf with (A) foxd3, (B) msxb, (C) snai1b, (D) tfap2a, (E) dlx3b and (F) ngn1 probes. (G) Whole mount immunostaining of zebrafish at 24 hpf with PHH3 (red) and DAPI (blue). (H) Quantitative analysis of immunostaining. (I) TUNEL staining at 24 hpf with TUNEL (red) and DAPI (blue). (J) Quantitative analysis of TUNEL staining. Data are presented as the mean ± standard deviation (n=5). *P<0.05 vs. WT. WT, wild-type; foxd3, forkhead box D3; msxb, muscle segment homeobox-B; snai1b, snail homolog 1b; tfap2a, transcription factor AP2A; dlx3b, distal-less 3; ngn1, neurog1; PHH3, phospho-histone H3; hpf, hours post fertilization; ns, not significant.

Expression Data

Genes:	dlx3b foxd3 msx1b neurog1 snai1b tfap2a
Fish:	TU mir1-1^{zf3464/zf3464} (TU)
Anatomical Term:	neural crest cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mir1-1^{zf3464/zf3464} (TU)
Observed In:	neural crest cell neural crest cell apoptotic process neural crest cell cell population proliferation neural crest cell differentiation neural crest cell migration
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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