FIGURE

Fig. 1

ID

ZDB-FIG-210412-6

Publication

Zhao et al., 2021 - MicroRNA-1 affects the development of the neural crest and craniofacial skeleton via the mitochondrial apoptosis pathway

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Fig. 1

Loss of miR-1 in zebrafish results in craniofacial, pigment cell and cardiac defects. In situ hybridization of miR-1 in (A) wild-type and (B) mutant zebrafish at 24 hpf. (C) Zebrafish larvae at 72 hpf with mutants exhibiting mandibular retrognathia (left arrow) and edema around the heart (right arrow). (D) Alcian blue staining at 96 hpf. (E) Quantitative analysis of b/a. (F) Quantitative analysis of c/a. a, width between ch; b, distance between mc and ch; and c, the distance between pq and ch. (G) Quantitative analysis of head size. (H) Distribution and number of iridophores at 72 hpf. Data are presented as the mean ± standard deviation (n=5). *P<0.05 and **P<0.01 vs. WT. WT, wild-type; hpf, hours post-fertilization; miR-1, microRNA-1; mc, Meckel's cartilage; pq, palatoquadrate; ch, ceratohyal cartilage.

Expression Data

Gene:	mir1-1
Fish:	TU mir1-1^{zf3464/zf3464} (TU)
Anatomical Terms:	head pectoral fin bud pharyngeal arch
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mir1-1^{zf3464/zf3464} (TU)
Observed In:	head iridophore melanocyte pectoral fin bud pericardium pharyngeal arch ventral mandibular arch
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

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