FIGURE

Figure 4

ID

ZDB-FIG-210119-26

Publication

Ohta et al., 2020 - Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

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Figure 4

Localization of Emx2 expression in wild-type (WT), loss of function (LOF), and gain of function (GOF) neuromasts at 2.0 dpf.

(A–C) Only hair cells (HCs) (B, Gfp) in the anterior neuromast of WT are positive for anti-Emx2 staining (C). Inset in B shows the bidirectional hair bundle orientation pattern. (D–F) No HCs (E) are positive for anti-Emx2 staining (F) in emx2 LOF neuromast and all hair bundles are oriented in P→A direction (E). (G–J) An emx2 GOF neuromast. (G) Merged image of Gfp (H), anti-Emx2 (I), and mCherry (J) expression. Anti-Emx2 staining only detected endogenous Emx2 in the anterior HCs (I), whereas exogenous Emx2 expression as indicated by mCherry expression is present in all HCs (J). All hair bundles are oriented in A→P direction and two immature HCs show the kinocilium located in the center (magenta arrows).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	emx2^idc5/idc5; vo8Tg
Observed In:	neuromast hair cell neuromast hair cell morphogenesis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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