FIGURE

Fig 5

ID

ZDB-FIG-200829-84

Publication

Zhang et al., 2020 - THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis

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Fig 5

Inactivation of <italic>thoc1</italic> induced apoptosis in neuromasts.

(a) Confocal microscopic imaging analysis of the hair cells in control and thoc1-KO Tg(pou4f3:gap43-GFP) at 3 and 4 dpf. Arrowheads indicate the abnormal hair cells. (b) TUNEL analysis of the neuromasts in control and thoc1-KO embryos at 4 dpf. Green: TUNEL staining. Blue: DAPI staining of the cell nuclei.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s356tTg + CRISPR1-thoc1
Knockdown Reagent:	CRISPR1-thoc1
Observed In:	neuromast hair cell neuromast support cell
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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