FIGURE

Fig 2

ID

ZDB-FIG-200829-80

Publication

Zhang et al., 2020 - THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis

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Fig 2

The expression of THOC1 in hair cells.

(a, b) Confocal microscopic imaging analysis of THOC1 antibody staining in mouse cochlea hair cells. THOC1 was enriched in outer hair cells (OHC) and inner hair cells (IHC) in the P0 mouse cochlea. Blue: DAPI staining of the cell nuclei. Red: Myosin 7a antibody staining marking hair cells. Green: THOC1 antibody staining. Bars, 40 μm. The region in yellow dash-line rectangle amplified in the white rectangle. Green arrowhead indicates nucleus; yellow arrowhead indicates cytoplasm. (c-e’) whole mount in situ hybridization analysis of expression of thoc1 in 3 dpf zebrafish. (c) Dorsal view, arrowheads indicate neuromasts. (d) Lateral view, arrowheads indicate neuromasts. (e) Lateral view, arrowheads indicate neuromasts. (e’) Lateral view, arrowheads indicate neuromasts. The magnified region of square in (e).

Expression Data

Gene:	thoc1
Fish:	AB
Anatomical Term:	neuromast
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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