FIGURE

Fig. 7.

ID

ZDB-FIG-200509-41

Publication

Veerman et al., 2019 - Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I_K,ACh)

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Fig. 7.

ACh induces more pronounced AP effects in S81L^homo compared to WT human atrial myocytes in computer simulations. (A,B) APs elicited at 1 Hz (top panels) and associated I_K,ACh (bottom panels) at baseline (dotted lines) and upon addition of 10 nmol l⁻¹ ACh (solid lines) in WT (A) and S81L^homo (B) human atrial myocytes. The horizontal double-headed arrow in panel A indicates the ACh-induced shortening of AP duration. The ‘wobbles’ in the time course of I_K,ACh in panel B are caused by the N-shape of the I_K,ACh current-voltage relationship (insets). The slanted arrows in the insets point to the I_K,ACh reversal potential (E_K) of −83.0 mV. (C,D) Shift in maximum diastolic potential (ΔMDP; C) and threshold stimulus current amplitude (D) at ACh concentrations ranging from 0.1 nmol l⁻¹ to 1 µmol l⁻¹. Note the logarithmic abscissa scale.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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