FIGURE

Fig. 4.

ID

ZDB-FIG-200509-38

Publication

Veerman et al., 2019 - Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I_K,ACh)

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Fig. 4.

CCh induces an extreme slowing of spontaneous beating in S81L^homo hiPSC-CMs, which is largely suppressed by I_K,ACh blockade through XEN-R0703. (A) Typical APs of an S81L^homo hiPSC-CM at baseline (top), upon application of 10 µmol l⁻¹ CCh (middle), and upon addition of 1 µmol l⁻¹ XEN-R0703 in the presence of 10 µmol l⁻¹ CCh (bottom). (B) Effects of CCh and XEN-R0703 on spontaneous AP frequency in four S81L^homo hiPSC-CMs. *P<0.05 (one-way repeated measures ANOVA followed by post-hoc Holm-Sidak test). XEN-R0703 restores the beating frequency of S81L^homo hiPSC-CMs to values similar to a baseline condition.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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