ZFIN Image: Veerman et al., 2019, Fig. 4.

Image

Figure Caption

Fig. 4.

CCh induces an extreme slowing of spontaneous beating in S81L^homo hiPSC-CMs, which is largely suppressed by I_K,ACh blockade through XEN-R0703. (A) Typical APs of an S81L^homo hiPSC-CM at baseline (top), upon application of 10 µmol l⁻¹ CCh (middle), and upon addition of 1 µmol l⁻¹ XEN-R0703 in the presence of 10 µmol l⁻¹ CCh (bottom). (B) Effects of CCh and XEN-R0703 on spontaneous AP frequency in four S81L^homo hiPSC-CMs. *P<0.05 (one-way repeated measures ANOVA followed by post-hoc Holm-Sidak test). XEN-R0703 restores the beating frequency of S81L^homo hiPSC-CMs to values similar to a baseline condition.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.