FIGURE

Figure 6.

ID

ZDB-FIG-200210-21

Publication

Chhabria et al., 2018 - The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish

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Figure 6.

Sodium nitroprusside reverses the effect of glucose on neurovascular coupling. (a)–(d) Time series of neuronal activation (ΔF/F_o) and tectal vessel RBC speed in zebrafish (5 larvae/group) exposed to: (a) 20 mM mannitol for 120 h from 4 to 9 dpf. (b) 20 mM mannitol for 120 h from 4 to 9 dpf and 0.1 mM SNP for 24 h from 8 to 9 dpf. (c) 20 mM glucose for 120 h from 4 to 9 dpf. (d) 20 mM glucose for 120 h from 4 to 9 dpf and 0.1 mM SNP for 24 h from 8 to 9 dpf. (e) Frequency of peaks of neuronal activation during baseline, response and recovery time periods in mannitol or glucose exposed larvae with or without co-treatment with 0.1 mM SNP (n = 20 larvae/group). (f) RBC speed for baseline, response and recovery for same animals in (e). (g) Beating heart rate (bpm) quantified for baseline, response and recovery time periods for larvae exposed to 20 mM mannitol, 20 mM glucose with or without SNP treatment. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Data are mean ± s.d.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s916Tg; sd2Tg; sh344Tg
Conditions:	chemical treatment by environment: glucose chemical treatment by environment: sodium nitroprusside
Observed In:	brain vasculature nucleate erythrocyte
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cereb. Blood Flow Metab.