FIGURE

Figure 5.

ID

ZDB-FIG-200210-20

Publication

Chhabria et al., 2018 - The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish

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Figure 5.

Sodium nitroprusside reverses the effect of glucose exposure on cerebrovascular patterning. (a) Gannt chart indicating treatment groups and duration of drugs exposures for experiments in Figures 6 and 7. (b) Representative micrographs of cerebral vessels of 9 dpf Tg(kdrl:mCherry) larvae exposed to mannitol or glucose ± SNP. (c) Quantification of number of tectal vascular branch points in all groups (n = 23 larvae/group). (d) Quantification of total tectal vessel length in same animals as in (c). (e) Mean tectal vessel radius for the same animals as in (c) (n = 23 larvae/group). (f) Histogram of radii of vessels in the left optic tectum in the same animals as in (c). Scale bar represents 20 µm. *p < 0.05, **p < 0.01, ***p < 0.005. Scale bar represents 20 µm. Data in (f) are mean ± s.d.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s916Tg; sd2Tg; sh344Tg
Conditions:	chemical treatment by environment: glucose chemical treatment by environment: sodium nitroprusside
Observed In:	brain vasculature
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cereb. Blood Flow Metab.