FIGURE

Figure 3.

ID

ZDB-FIG-200205-26

Publication

Nichols et al., 2020 - Functional Regeneration of the Sensory Root via Axonal Invasion

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Figure 3.

Induction of Invasion Components in DRG Neurons Promotes Regeneration.

(A–C) Z-projection time-lapse images of avulsed DRG in Tg(sox10:gal4); Tg(uas:lifeact-gfp) animals expressing uas:src-mcherry (A), uas:CA-src-mcherry (B), or uas:CA-src-mcherry and treated with Taxol (C). Graphs show Lifeact-GFP intensity tracings throughout regeneration. The green arrow denotes a stable invasive structure. Red arrows and brackets represent peaks of Lifeact-GFP.

(D) Actin concentrate duration in Src DRG (n = 6), CA-Src DRG (n = 6), and CA-Src+Taxol DRG (n = 5).

(E) Regeneration outcomes in DRG expressing sox10:Src, sox10:CA-Src, or sox10:CA-Src+Taxol or radial glial expressing gfap:CA-Src.

(F) Percentage of time points the regenerating growth cone navigated using each actin organization.

Tukey’s HSD was used in (D) and two-way ANOVA was used in (F). Scale bar, 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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