FIGURE

Fig. 8.

ID

ZDB-FIG-200116-8

Publication

Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

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Fig. 8.

Antioxidant treatment partially rescues hair cell numbers in the inner ear and the lateral line of ak2^hg14 mutants. (A,B) Average number of mature hair cells in the inner ear cristae (top) and anterior macula (bottom) of 3 dpf (A) or in the inner ear cristae of 4 dpf (B) ak2^hg14 embryos treated with different concentrations of GSH (100-300 µM). Results are shown as mean±s.e.m. (one-way ANOVA, followed by Tukey's post hoc test; P<0.001). (C) Summary of the percentage of rescue induced by the different GSH treatments on the inner ear cristae and anterior macula at 3 and 4 dpf. (D) Quantitative analysis of the rescue induced by GSH treatments on the expression of alkaline phosphatase in PLL neuromasts of 4 and 5 dpf ak2^hg14 and control embryos. Numbers above bars indicate the total amount of embryos used for the analysis. a, anterior; m, medial; p, posterior; UNTR, untreated. A one-way ANOVA (followed by Tukey's post hoc test; P<0.001) was used to compare groups of fish treated differently.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ak2^hg14/hg14; s356tTg
Condition:	chemical treatment by environment: glutathione
Observed In:	auditory receptor cell hair cell anterior macula
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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