FIGURE

Fig. 7

ID

ZDB-FIG-190820-30

Publication

Zhu et al., 2019 - Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms

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Fig. 7

KV/cilia related signaling pathway analysis in apela morphants. (A-C) Compared with the control embryos (A. a1, B. b1 and C. c1), the expression of fgf8 and the downstream gene dnh9 were not changed in apela morphants (A. a2, 84.4%, n=32; C. c2, 65.6%, n=32), but the expression of erm was up regulated in apela morphants (B. b2, 85%, n=20). (E-D) Foxj1a was expressed in DFCs. Compared with that in control embryos (E. e1, 82.8%, n=35), foxj1awas down regulated in apela morphants (E. e3, 63.5%, n=104). The average area of foxj1a expression in control embryos and apela morphants were 3.87 x10³ uM² (n=21) and 2.75 x10³ uM², respectively (D, n=21, p<0.01). Q-PCR experiment indicated that foxj1a expression was down regulated with 0.61 folds compared with that in control embryos (F). *, p<0.05; **, p<0.01.

Expression Data

Genes:	dnah9 etv5b fgf8a foxj1a
Fish:	AB AB + MO1-apela
Knockdown Reagent:	MO1-apela
Anatomical Terms:	forerunner cell group Kupffer's vesicle whole organism
Stage Range:	90%-epiboly to 1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-apela
Knockdown Reagent:	MO1-apela
Observed In:	forerunner cell group Kupffer's vesicle whole organism
Stage Range:	90%-epiboly to 1-4 somites

Phenotype Detail

Acknowledgments

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