FIGURE

Fig. 7

ID

ZDB-FIG-190328-27

Publication

Zheng et al., 2018 - Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model

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Fig. 7

Stx1b morpholino oligos injection suppressed BBR activation on STX1B expression in the PTZ-model larvae. (A) Hybridization in situ results show that a change of the stx1b messenger RNA level in the larval (7 dpf) brain was induced by BBR with stx1b morpholino oligos injection in the PTZ-model zebrafish, as compared with in the wild-type, stx1b morpholino oligos injection, and PTZ plus stx1b morpholino oligos groups (n = 20). (B) Western blotting results indicated a change of the STX1B protein level similar to the change of the stx1b messenger RNA level under the same treatments (n = 3). ^&P < 0.05 vs. PTZ plus stx1b morpholino oligos model; ^𝜃P < 0.05 and ^𝜃𝜃P < 0.01 vs. stx1b morpholino oligos model.

Expression Data

Gene:	stx1b
Antibody:	Ab1-stx1b
Fish:	AB AB + MO1-stx1b AB + MO2-stx1b
Conditions:	chemical treatment by environment: pentetrazol chemical treatment by environment: berberine
Knockdown Reagents:	MO1-stx1b MO2-stx1b
Anatomical Terms:	brain whole organism
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-stx1b AB + MO2-stx1b
Conditions:	chemical treatment by environment: pentetrazol chemical treatment by environment: berberine
Knockdown Reagents:	MO1-stx1b MO2-stx1b
Observed In:	brain whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.