FIGURE

Fig. 4

ID

ZDB-FIG-180502-27

Publication

Chou et al., 2017 - A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish

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Fig. 4

Spatial positioning of anterior neuromasts regulates diverse Tmc2b dependence. a Confocal micrographs of MI1 hair cells incubated with 4-Di-2-ASP from tmc2b ^+/− (left) or tmc2b ^−/− (right) animals at 6 dpf, viewed under low gain. b Hair cells from a, right, viewed under high gain. c Percentages of MI1 hair cells at different fluorescence intensities (n = 5). d Images and e percentages of hair cells at different fluorescence intensities from IO4 neuromasts (n = 5). f Percentages of hair cells of ALL neuromasts that take up 4-Di-2-ASP. ****One-way ANOVA with Holm-Sidak’s multiple comparisons test P < 0.0001. n values (het/homo): IO4 = 6/4, MI1 = 7/5, M2 = 5/3, O1 = 5/2, O2 = 5/4, OP1 = 5/3, MI2 = 5/5. g Mean whole-neuromasts normalized fluorescence intensity ratios, I _tmc2b ^−/−/ (I _tmc2b ^+/+, I _tmc2b ^+/−). n values ≥ 5. Scale bar = 6 µm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tmc2b^cwr8/cwr8 tmc2b^cwr8/+
Observed In:	infraorbital lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound mandibular lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound middle lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound opercular lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound otic lateral line neuromast detection of mechanical stimulus involved in sensory perception of sound
Stage:	Day 6

Phenotype Detail

Acknowledgments

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