FIGURE

Fig. S6

ID

ZDB-FIG-180105-33

Publication

Wu et al., 2017 - Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development

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Fig. S6

Overexpression of cpn1 causes circulation defects and pericardial edema. (A-C) Injection of cpn1 mRNA into Tg(fli:eGFP^y1 ; gata1:dsRed) embryos causes circulation defect at ISV-DLAV at 48hpf. Quantification data showed overexpressing cpn1 embryos with 90% defects in circulation compared to control (n=10 for both conditions). (D-F) At 72hpf, overexpresion of cpn1 shows pericardial edema (arrow in E). Quantification of percentage of pericardial edema showed ~70 % increase in cpn1 mRNA injected embryos compared to control (n=33 in control and n=28 in cpn1 mRNA injection) at 72hpf. Scale bars are 100 μm for A, B and 200 μm for D, E.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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