FIGURE

Fig. 6

ID

ZDB-FIG-170424-9

Publication

Schmitner et al., 2017 - ptf1a⁺ , ela3l^- cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae.

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Fig. 6

Ptf1a⁺ cells as a source for exocrine cell regeneration. (A-C) Confocal images of the pancreatic head region of EdU-labeled Tg(ela:casp8; ptf1a:eGFP) at 0 dpa (A), 6 dpa (B) and 8 dpa (C) following a 7-9 dpf ablation treatment showing that during regeneration, ptf1a⁺, ela3l⁻ cells (white arrows) rarely proliferate and differentiated exocrine cells reconstitute the exocrine pancreas. (D) Absolute numbers of all ptf1a⁺ cells in the pancreatic head region, proliferating ptf1a⁺ cells and GFP⁺, E2Crimson⁻ and GFP⁺, E2Crimson⁺ cells. (E) Relative amount of EdU⁺, ptf1a⁺, E2Crimson⁻ and EdU⁺, ptf1a⁺, E2Crimson⁺ cells. Mean+s.e.m. Scale bar: 20 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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