FIGURE

Fig. S2

ID

ZDB-FIG-170220-10

Publication

Mayrhofer et al., 2017 - A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth

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Fig. S2

Tumours can be induced by different oncogenes. A-D) H&E staining of lesions induced by somatic expression of different oncogenes. Boxed area indicates enlargement shown in A'-D', respectively. A''-D'') Immunostaining for BrdU of lesions induced by somatic expression of different oncogenes. Arrows point at lesions. E) Western blot showing the levels of phosphorylated ERK (P-ERK) and actin in control brain (lane 1), heterotopia (lane 2), zic:EGFR_VIIIsomatic (lane 3), zic:Xmrk_somatic (lane 4), zic:AKT-BFP_somatic (lane 5), zic:BRAFM^E600 _somatic (lane 6), zic:GFP-KRAS^V12 _somatic (lane 7) and zic:GFP-HRAS^V12 _somatic (lane 8). Scale bars: A-C = 100 μm; D = 1 mm; A'-D' = 50 μm; A''-D'' = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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