FIGURE

Fig. 2

ID

ZDB-FIG-170220-6

Publication

Mayrhofer et al., 2017 - A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth

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Fig. 2

Somatic expression of oncogenic RAS induces tumour development and heterotopia. (A-C) Fluorescence images of 2 months post-fertilisation (mpf) zebrafish brains of zic:Gal4 (A) and zic:RAS_somatic (B,C) fish showing (A) a control brain, (B) tumours in the telencephalon (T), diencephalon (D) and IVth ventricle region (V), and (C) heterotopia (H). (D) Graph representing the frequency of different lesions resulting from induction of UAS:GFP-HRAS^V12 expression (n=134, of which T=83, D=40, V=44, H=67). (E-G) Volume rendering of 3D reconstructions of two brains with tumours (E,F, green areas) and a brain with heterotopia (G, white arrow) shown as dorsal view (inset) and one sagittal section (large image). (H) 3D reconstruction and volume rendering of a brain showing different tumour expansions (colour coded according to histological and anatomical features and GFP expression). Scale bars: 2 mm in A-C.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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