FIGURE

Fig. 7

ID

ZDB-FIG-160915-22

Publication

Powell et al., 2016 - Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish

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Fig. 7

Wtip is required for early left-right patterning. Dorsal views, anterior to the bottom of the panels. (A-D,K) lefty1 and lefty2, (E-H,L) spaw and (I,J,M) bmp4 expressions in (A-J) 22-somite stage embryos. Normally, (A,E,I) left1+2, spaw and bmp4 transcripts expressed in the left cardiac lateral plate mesoderm, (B,F,J) have bilateral, (C,G) right and (D,H) absent expression in wtip morphants (1.035 pmol/embryo). Bar chart details the left-right patterning for control and wtip morphants. Wtip, Wilm′s tumor 1 interacting protein; lefty1, left right determination factor 1; spaw, southpaw; bmp4, bone morphogenic factor 4; conMO, control morpholino oligonucleotide.

Expression Data

Genes:	bmp4 lft1 spaw
Fish:	AB AB + MO2-wtip
Knockdown Reagent:	MO2-wtip
Anatomical Terms:	heart rudiment left side heart rudiment right side lateral plate mesoderm left side lateral plate mesoderm right side
Stage:	26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO2-wtip
Knockdown Reagent:	MO2-wtip
Observed In:	determination of heart left/right asymmetry determination of left/right asymmetry in lateral mesoderm heart rudiment right side lateral plate mesoderm right side
Stage:	26+ somites

Phenotype Detail

Acknowledgments

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