FIGURE

Fig. S3

ID

ZDB-FIG-151008-24

Publication

Hu et al., 2015 - Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos

Other Figures

All Figure Page

Back to All Figure Page

Fig. S3

Dopaminergic phenotype in zebrafish larvae injected with ddb1_MO1.

(A-I) The th expression pattern in wild type control larvae (A-C), in larvae injected with ddb1_MO1 (4 ng/embryo) (D-F), and larvae injected with ddb1_MO1 (4 ng/embryo) and the same amount of p53_MO (G-I) was analyzed by WISH. (A, D, G) lateral views and (B-C, E-F, H-I) dorsal views. Red arrows point at affected th-expressing neurons in the pretectum (D-E, G-H) and retina (F, I). Abbreviations used: AAN, arch-associated neurons; H, hypothalamus; LC, locus coeruleus; MO, medulla oblongata; OB, olfactory bulb; Pr, pretectum; PT, posterior tuberculum; SP, subpallium; sym, sympathetic neurons; VT, ventral thalamus. Anterior towards the left. Scale bar: 100 µm.

Expression Data

Gene:	th
Fish:	WT WT + MO1-ddb1 WT + MO1-ddb1 + MO4-tp53
Knockdown Reagents:	MO1-ddb1 MO4-tp53
Anatomical Term:	dopaminergic neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-ddb1 WT + MO1-ddb1 + MO4-tp53
Knockdown Reagents:	MO1-ddb1 MO4-tp53
Observed In:	pretectum dopaminergic neuron retina dopaminergic neuron
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One