FIGURE

Fig. 7

ID

ZDB-FIG-151008-21

Publication

Hu et al., 2015 - Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos

Other Figures

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Fig. 7

Reduced ccna2 and ccnd1 expression in ddb1^m863 mutant embryos.

(A-D) Expression pattern of ccna2 in wild type siblings. (E-H) Slight reduction of ccna2 expression was detected in the tpz (arrow in E-F) and CMZ (arrow in G) in ddb1^m863 mutants. (I-P) The expression pattern of ccnd1 in wild type and homozygous ddb1^m863 embryos. The transcripts of ccnd1 were slightly decreased in homozygous mutants (M-P). Arrows represent the altered expression of ccnd1 in the tectal proliferation region (M, N), cerebellum (M), and retina (O, P). Abbreviations used: ba, branchial arches; Cce, cerebellum; j, jaw; hb, hindbrain; tel, telencephalon; ret, retina; tpz, tectal proliferation region; VZ, ventricular zone. Anterior towards the left. Scale bars: 100 µm.

Expression Data

Genes:	ccna2 ccnd1
Fish:	WT ddb1^m863/m863
Anatomical Terms:	cerebellum ciliary marginal zone hindbrain proliferative region optic tectum proliferative region ventricular zone
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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