FIGURE

Fig. 1

ID

ZDB-FIG-150916-16

Publication

Pagán et al., 2015 - Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment

Other Figures

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Fig. 1

csf1r Mutant Zebrafish Are Hypersusceptible to M. marinum Infection

(A) Survival of adult zebrafish injected intraperitoneally with ~273 M. marinum or an equivalent volume of PBS (mock). n = 30 for each group.

(B) Bacterial burdens (CFU, colony-forming units) of adult zebrafish infected intraperitoneally with ~115 CFU of M. marinum. Horizontal lines indicate mean values.

(C) Survival of zebrafish larvae injected with PBS (mock) or ~193 M. marinum via the caudal vein. n = 30 for each group.

(D and E) Representative images (D) and mean bacterial burden (E) of larvae infected with ~200 fluorescent M. marinum via the caudal vein. Scale bar, 300 µm. Error bars indicate standard error of the mean (SEM).

Statistical significance was determined by log-rank test (A, C) or two-tailed unpaired Student’s t test (B, E). Data are representative of more than three experiments. See also Figures S1-S3 and Movies S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB csf1ra^{j4blue/j4blue}
Condition:	bacterial treatment
Observed In:	whole organism
Stage Range:	Days 7-13 to Adult

Phenotype Detail

Acknowledgments

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