FIGURE

Fig. 6

ID

ZDB-FIG-150916-18

Publication

Pagán et al., 2015 - Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment

Other Figures

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Fig. 6

Increasing Macrophage Supply in Wild-Type Zebrafish Delays Granuloma Necrosis

(A-D) One-cell stage WT mpeg1:tdTomato embryos were injected with vehicle (mock) or ~2 nl of 200 ng/µl in vitro-transcribed csf1a RNA. (A) Schematic of csf1a overexpression construct and maximum intensity projections of the caudal hematopoietic tissue of 2-day-old larvae. Scale bar, 100 µm. (B) Number of macrophages in the CHT of 2 dpf larvae. Horizontal lines depict means. Percentage of cording in WT or csf1r mutant larvae 6 dpi (C) or 7 dpi (D) with ~200 M. marinum expressing tdKatushka2. Statistical significance determined by two-tailed unpaired Student’s t test (B) or Fisher’s exact test (C and D).

Expression Data

Gene:	Tomato
Fish:	w201Tg
Anatomical Term:	macrophage
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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