FIGURE

Fig. 3

ID

ZDB-FIG-150915-26

Publication

Willems et al., 2015 - The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish

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Fig. 3

Knock-down of lrp5 results in reduced canonical Wnt signaling.

(A-D) TOPdGFP embryos at 20 ss analyzed for gfp transcription. (A,B) Uninjected control, (C,D) lrp5 morphant. Note that gfp transcripts are down-regulated in morphants. (E-H) 20 ss embryos expressing lef1. (E,F) Wild-type embryo, (G,H) lrp5 morphant. Note that lef1 expression is down-regulated in morphants, particularly in the CNCC regions (see asterisk in G and arrows in H). Anterior is to the left in all images.

Expression Data

Genes:	GFP lef1
Fish:	WT WT + MO3-lrp5 + MO4-lrp5 w25Tg w25Tg + MO3-lrp5 + MO4-lrp5
Knockdown Reagents:	MO3-lrp5 MO4-lrp5
Anatomical Terms:	cranial neural crest cell hindbrain midbrain hindbrain boundary tail bud
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-lrp5 + MO4-lrp5 w25Tg + MO3-lrp5 + MO4-lrp5
Knockdown Reagents:	MO3-lrp5 MO4-lrp5
Observed In:	cranial neural crest cell cranial neural crest cell canonical Wnt signaling pathway hindbrain hindbrain canonical Wnt signaling pathway midbrain hindbrain boundary tail bud
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

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