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Fig. 3 Knock-down of lrp5 results in reduced canonical Wnt signaling.
(A-D) TOPdGFP embryos at 20 ss analyzed for gfp transcription. (A,B) Uninjected control, (C,D) lrp5 morphant. Note that gfp transcripts are down-regulated in morphants. (E-H) 20 ss embryos expressing lef1. (E,F) Wild-type embryo, (G,H) lrp5 morphant. Note that lef1 expression is down-regulated in morphants, particularly in the CNCC regions (see asterisk in G and arrows in H). Anterior is to the left in all images.
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