FIGURE

Fig. 2

ID

ZDB-FIG-150504-18

Publication

Kantarci et al., 2015 - Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling

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Fig. 2

Tfap2a enhances otic neurogenesis.

(A-L) Cross-sections (medial left, dorsal up) through the otic region just posterior to the utricular macula showing ngn1 expression in +/+ control embryos, hs:tfap2a embryos and tfap2a^-/- mutants at the indicated times. Wild-type and hs:tfap2a embryos were heat shocked as indicated in each panel. Overexpression of tfap2a increases the number of neuroblasts in the otic vesicle whereas loss of tfap2a slows down and decreases otic neurogenesis. The outer and inner edges of the otic vesicle are outlined in each image. (M, N) Mean and standard deviation of the total number of ngn1 positive cells in the otic epithelium from 24 to 32 hpf for the genotypes indicated in the color key (counted from serial sections, n = 3–7 ears per time point). Asterisks (*) indicate statistically significant differences between groups indicated by brackets (N) or compared to control embryos (M).

Expression Data

Gene:	neurog1
Fish:	AB tfap2a^m819/m819 x24Tg
Condition:	heat shock
Anatomical Term:	otic vesicle neuroblast (sensu Vertebrata)
Stage Range:	Prim-5 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB tfap2a^m819/m819 AB + MO4-tfap2a x24Tg
Condition:	heat shock
Knockdown Reagent:	MO4-tfap2a
Observed In:	otic vesicle otic vesicle neuroblast (sensu Vertebrata) otic vesicle neuroblast fate specification
Stage Range:	Prim-5 to High-pec

Phenotype Detail

Acknowledgments

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