FIGURE

Fig. 10

ID

ZDB-FIG-150504-26

Publication

Kantarci et al., 2015 - Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling

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Fig. 10

Bmp signaling mediates the effects of Tfap2a on SAG development.

(A-L) Cross sections (medial left, dorsal up) through the otic vesicle just posterior to the utricular macula showing expression of her4 (A-D) and deltaB (E-H) at 26 hpf and ngn1 (I-L) at 28 hpf in control embryos (A, E, I), hs:tfap2a embryos (B, F, J), DM-treated hs:tfap2a embryos (C, G, K) and DM-treated wild-type embryos (D, H, L). All specimens were treated with 1% DMSO and heat-shocked at 24 hpf. (M-P) Mean and standard deviation of the total number of deltaB or her4 expressing cells inside the otic vesicle or in the TA pool at 26 hpf under conditions indicated in the color key (counted from serial sections, n = 3–6 ears per time point). (Q-S) Mean and standard deviation of the total number of ngn1+ cells at 28 hpf (Q) and Isl1+ SAG neurons at 30 hpf (R) and 37 hpf (S) under the conditions indicated in the color key. Asterisks (*) indicate statistical differences between the groups indicated in brackets.

Expression Data

Genes:	dlb her4.1 neurog1
Fish:	AB x24Tg
Conditions:	heat shock chemical treatment: dorsomorphin, heat shock
Anatomical Term:	otic vesicle neuroblast (sensu Vertebrata)
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB x24Tg
Conditions:	heat shock chemical treatment: dorsomorphin, heat shock
Observed In:	otic vesicle neuroblast fate specification otic vesicle Notch signaling pathway statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion neuron statoacoustic (VIII) ganglion neuron differentiation
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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