FIGURE

Fig. 4

ID

ZDB-FIG-150413-11

Publication

Ma et al., 2015 - Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

fgf10a RNA levels are specifically reduced at the posterior prosensory domain in jag1b^-/- embryos. (A-F) Whole-mount in situ hybridization of jag1b^+/+, jag1b^+/- and jag1b^-/- embryos at 30 and 34hpf. Lateral views. Scale bar: 20µm. (G-H′′) Posterior cristae in jag1b^+/- embryos treated with DMSO (G-G′′) or SU5402 (H-H′′) at 24-26hpf. Dorsolateral views. Scale bars: 50µm in G-H′; 10µm in G′′ and H′′. (I) TUNEL staining of jag1b^+/- embryos treated with DMSO or SU5402. Apoptosis signals are detected in the posterior prosensory domain of the SU5402-treated jag1b^+/- embryos at 42hpf. Dorsolateral views. Scale bars: 40µm (left) and 20µm (right). (J) Phalloidin staining of jag1b^+/- embryos treated with DMSO or SU5402. Lateral views. Scale bar: 50µm. Anterior towards the left and dorsal upwards. Boxed regions are enlarged on the right. Arrows and arrowheads indicate posterior crista regions.

Expression Data

Genes:	EGFP fgf10a
Fish:	WT jag1b^gd2Gt/gd2Gt jag1b^gd2Gt/+
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	otic vesicle otic vesicle anterior crista otic vesicle lateral crista
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development