FIGURE

Fig. 3

ID

ZDB-FIG-150413-10

Publication

Ma et al., 2015 - Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death

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Fig. 3

Jag1b is required for survival of the posterior prosensory cells. (A) Confocal images of the otic vesicle of embryos at 24hpf. Lateral views. Scale bar: 50µm. (B) Whole-mount in situ hybridization of otic marker genes at 24hpf. Scale bar: 20µm. (C) Time-lapse live imaging of the developing posterior prosensory domain. The posterior sensory cells are gradually lost in jag1b^-/- embryos. Scale bar: 10µm. (D) TUNEL staining of embryos at 34hpf and 40hpf. At 40hpf, apoptosis signals are detected only in the posterior prosensory domain of jag1b^-/- embryos. Dorsolateral views. Scale bars: 40µm (left) and 20µm (right). Anterior towards the left and dorsal upwards. Boxed regions are enlarged on the right.

Expression Data

Genes:	bmp4 cldna EGFP fgf8a otx2a
Fish:	WT jag1b^gd2Gt/gd2Gt jag1b^gd2Gt/+
Anatomical Terms:	otic vesicle otolith
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jag1b^gd2Gt/gd2Gt
Observed In:	otic vesicle anterior crista otic vesicle posterior crista
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

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