FIGURE

Fig. 7

ID

ZDB-FIG-150311-79

Publication

Terashima et al., 2014 - Odd skipped related 1 is a negative feedback regulator of Nodal-induced endoderm development

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Fig. 7

osr1 expression is independent of sox32 and acts to limit endodermal cell differentiation. A, B: Lateral views, dorsal on the right. A′, B′: Animal pole views, dorsal bottom. osr1 expression in the germ ring (A, A′) is unaffected in sox32 morphant embryos, which lack all endoderm derivatives. C–J: Animal pole views, dorsal bottom. foxa2 expression in control (C), osr1 knockdown (D), sox32 knockdown (E), and combined osr1, sox32 knockdown (F) reveals increased foxa2-expressing cells in osr1- and combined osr1-, sox32-deficient embryos. sox17 expression in control (G), osr1 knockdown (H), sox32 knockdown (I), and combined osr1, sox32 knockdown (J) reveals increased sox17-expressing cells in osr1- and combined osr1-, sox32-deficient embryos.

Expression Data

Genes:	foxa2 osr1 sox17
Fish:	AB/TU AB/TU + MO2-osr1 AB/TU + MO2-sox32 AB/TU + MO2-osr1 + MO2-sox32
Knockdown Reagents:	MO2-osr1 MO2-sox32
Anatomical Terms:	germ ring presumptive endoderm
Stage:	Shield

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU + MO2-osr1 AB/TU + MO2-sox32 AB/TU + MO2-osr1 + MO2-sox32
Knockdown Reagents:	MO2-osr1 MO2-sox32
Observed In:	endodermal cell endodermal cell differentiation hypoblast
Stage:	Shield

Phenotype Detail

Acknowledgments

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