FIGURE

Fig. 7

ID

ZDB-FIG-140717-16

Publication

Lele et al., 2002 - parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube

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Fig. 7

pac mutants display loss of membrane-associated β-catenin and enhanced cell proliferation in dorsal regions of midbrain and hindbrain. (A,B) Anti-b catenin immunostaining on 2 mm confocal cross-sections through the hindbrain of wild-type (A) and pac^paR2.10 mutant sibling (B); 12-somite stage. (C-F) Anti-phospH3 immunostaining of wild-type sibling (C,E) and pac^fr7 mutant (D,F) embryos of the 12-somite stage; flat mounts of whole embryos (C,D), and representative cross-sections at the hindbrain level (E,F). Mitotic cells in the lateralmost position (indicated by arrowheads) are not part of the neural tube and are probably migrating neural crest cells. In A,B,E,F, the neural tube is outlined by dots. Arrows in F point to ectopic phospH3-positive cells in alar region of mutant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cdh2^fr7/fr7
Observed In:	cell proliferation in hindbrain cell proliferation in midbrain neural tube cell
Stage:	10-13 somites

Phenotype Detail

Acknowledgments

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