FIGURE

Fig. 4

ID

ZDB-FIG-140527-14

Publication

Jiang et al., 2014 - Gene-expression analysis of hair cell regeneration in the zebrafish lateral line

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Fig. 4

Inhibition of Notch and Fgf pathways is accompanied with cell cycle reentry immediately after hair cell ablation. (A, C, and D) In situ hybridization of Notch pathway, Fgf pathway, and cell cycle genes in 5-dpf untreated and neomycin-treated larvae. (A) The Notch pathway inhibitor numb is increased at 1 h after neomycin. The Notch target genes her4.1, notch3, and sox2 are decreased at 1 h and up-regulated at 3 h after neomycin treatment. atoh1a is up-regulated starting at 1 h after neomycin, and its target dld is increased at 5 and 10 h. (C) fgf3 and its target pea3 are down-regulated at 1 and 3 h after neomycin treatment. (D) Cell cycle inhibitory genes cdkn1b, cdkn1c, and rbl2 are decreased at 1 and 3 h after neomycin compared with control. (B and E) Heat maps of selected Notch pathway genes and cell cycle genes.

Expression Data

Genes:	atoh1a cdkn1bb cdkn1ca dld etv4 fgf3 her4.1 notch3 numb rbl2 sox2
Fish:	WT
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	neuromast
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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