Gene
sox2
- ID
- ZDB-GENE-030909-1
- Name
- SRY-box transcription factor 2
- Symbol
- sox2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Exhibits chromatin binding activity and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; fin regeneration; and otic placode development. Predicted to localize to nuclear transcription factor complex. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; and syndromic microphthalmia. Is expressed in several structures, including immature eye; nervous system; neural keel; neural rod; and presumptive structure. Orthologous to human SOX2 (SRY-box transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 176 figures from 107 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb236 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic microphthalmia 3 | Alliance | Microphthalmia, syndromic 3 | 206900 |
| syndromic microphthalmia 3 | Alliance | Optic nerve hypoplasia and abnormalities of the central nervous system | 206900 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily | Transcription factor SOX |
|---|---|---|---|---|
|
UniProtKB:Q6P0E1
|
315 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-sox2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
40 | |
| Ab5-sox2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
5 | |
| Ab1-sox2 | polyclonal | Rabbit |
|
Millipore
|
25 | ||
| Ab13-sox2 | monoclonal | IgG1 | Mouse |
|
GeneTex
|
4 | |
| Ab2-sox2 | polyclonal | IgG | Rabbit |
|
LifeSpan BioSciences, Inc.
|
4 | |
| Ab4-sox2 | polyclonal | IgG | Goat |
|
R&D Systems
|
8 |
Plasmids