Gene
cdkn1ca
- ID
- ZDB-GENE-040123-1
- Name
- cyclin dependent kinase inhibitor 1Ca
- Symbol
- cdkn1ca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have cyclin-dependent protein serine/threonine kinase inhibitor activity and kinase activity. Involved in cell fate specification; glial cell differentiation; and negative regulation of mitotic cell cycle. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Is expressed in several structures, including mesoderm; muscle; nervous system; neural tube; and notochord. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb961 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Osborn et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Beckwith-Wiedemann syndrome | Alliance | Beckwith-Wiedemann syndrome | 130650 |
| IMAGe syndrome | Alliance | IMAGE syndrome | 614732 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase inhibitor domain | Cyclin-dependent kinase inhibitor domain superfamily |
|---|---|---|---|
|
UniProtKB:Q6IQT7
|
212 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkn1ca-201
(1)
|
Ensembl | 1,566 nt | ||
| mRNA |
cdkn1ca-202
(1)
|
Ensembl | 1,953 nt |
Interactions and Pathways
No data available
Plasmids
No data available