FIGURE

Fig. 3

ID

ZDB-FIG-131213-13

Publication

Geng et al., 2013 - Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene

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Fig. 3

Expression of genes involved in endolymph homeostasis in the lau mutant ear. (A-D) The endolymphatic duct, marked by expression of bmp4 (arrowheads, A,B) and foxi1 (C,D), appears to develop normally in lau mutants. The three cristae also express bmp4 normally (asterisks, A,B). (E-J) Expression of ion transporter genes in the lau mutant ear. (E,F) Expression of the atp1a1a.4 subunit of Na⁺/K⁺-ATPase1 is more diffuse and lacking from the ventral pillar (vp). (G-J) There is a substantial reduction in both kcnq1 and nkcc1 expression. Abbreviation: vp, ventral pillar (E) or ventral projection (F). Alleles: B,D,H,J, tk256a; F, tb233c. Scale bars: 50 μm.

Expression Data

Genes:	atp1a1a.4 bmp4 foxi1 kcnq1.1 slc12a2
Fish:	WT adgrg6^{tb233c/tb233c} adgrg6^{tk256a/tk256a}
Anatomical Terms:	anterior semicircular canal endolymphatic duct lateral semicircular canal pillar of the lateral semicircular canal posterior semicircular canal semicircular canal
Stage Range:	Long-pec to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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