Gene

foxi1

ID

ZDB-GENE-030505-1

Name

forkhead box i1

Symbol

foxi1 Nomenclature History

Previous Names

nos
cb724 (1)
hearsay
hsy
no soul
quadro (1)
quo(l)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity. Involved in several processes, including animal organ development; epidermal cell fate specification; and neuron development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Is expressed in several structures, including ectoderm; epibranchial ganglion; head; neural crest; and neurogenic field. Orthologous to human FOXI1 (forkhead box I1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

70 figures from 46 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb724 (51 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 38 figures from 19 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxi1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 4	Alliance	Enlarged vestibular aqueduct	600791

Associated With foxi1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Family	IPR050211	Forkhead box domain-containing protein
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily