FIGURE

Fig. S7

ID

ZDB-FIG-131010-16

Publication

D'Aniello et al., 2013 - Depletion of Retinoic Acid Receptors Initiates a Novel Positive Feedback Mechanism that Promotes Teratogenic Increases in Retinoic Acid

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Fig. S7

RARαb1 and RARαb2 function partially redundantly to promote forelimb development. (A–C) Control sibling, RARαb1 deficient, and RARαb2 deficient embryos. Images in A–C are dorsal views with anterior to the left. Arrows in B indicate smaller forelimbs. (D) Percentage of control sibling (n = 20), RARαb1 deficient (n = 20), and RARαb2 deficient (n = 20) embryos with normal, small or no forelimbs. An optimal dose of the rarαb1 and rarαb2 MOs was used for experiments in D. (E) Percentage of embryos with normal, small, or no forelimbs after injection with a suboptimal dose of rarαb1 MO (n = 28), a suboptimal dose of rarαb2 MO (n = 26), and co-injected with suboptimal doses of the rarαb1 and rarαb2 MOs (n = 17). (F–H) ISH of tbx5a, a forelimb marker, in control sibling, RARαb1 deficient, RARαb2 deficient embryos. Arrows in F–H indicate tbx5a expression the LPM. (I) Areas of the amount of cells expressing the tbx5a at 24 hpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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