FIGURE

Fig. 3

ID

ZDB-FIG-130220-8

Publication

Ding et al., 2013 - Redundant roles of PRDM family members in zebrafish craniofacial development

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Fig. 3

prdm3 and prdm16knockdown causes a reduction in the NCC expression domains of dlx2a at 24 hpf and barx1 at 48 hpf. A-C: Whole mount embryo ISH shows that pharyngeal arch marker dlx2a is expressed in the post-migratory neural crest region in control (A), prdm3 e3i3 (B), and prdm16 ATG (C) morphants at 24 hpf. dlx2a expression in prdm3 and prdm16 morphants shows a significant reduction in the anterior expression domain, and a mild reduction anteriorly relative to controls. D-F: barx1 expression in cranial NCC condensations is significantly reduced in the neurocranium (n) and arch 1 (1), dorsal and ventral domains within arch 2 (2d and 2v), and a domain representing arches 6 and 7 (6/7) in prdm3 (E) and prdm16 (F) morphants at 48 hpf as compared to controls (D). Arrows indicate notably reduced expression domains in prdm3 and prdm16 morphants. Anterior is to the left.

Expression Data

Genes:	barx1 dlx2a
Fish:	WT WT + MO2-mecom WT + MO2-prdm16
Knockdown Reagents:	MO2-mecom MO2-prdm16
Anatomical Terms:	neurocranium pharyngeal arch 1 pharyngeal arch 2 pharyngeal arch 3 pharyngeal arch 6 pharyngeal arch 7
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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