FIGURE

Fig. 8

ID

ZDB-FIG-121210-28

Publication

Shin et al., 2012 - Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

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Fig. 8

nf1 mutants display decreased lateral stripe melanophores. (A-D) Lateral stripe melanophores of wild-type (A,B) larvae demonstrate a normal uniform pattern that is absent in nf1a^-/-; nf1b^-/- larvae (C,D) at 6 dpf. The brackets in D highlight regions where melanophores are absent. (E) Quantification of lateral stripe melanophores from wild-type (n=26), nf1a^+/-; nf1b^-/- (n=30), nf1a^-/-; nf1b^+/+ (n=14), nf1a^-/-; nf1b^+/- (n=26) and nf1a^-/-; nf1b^-/- (n=12) larvae at 6 dpf. Each point represents the number of lateral stripe melanophores in an individual embryo and red lines indicate mean values. *P<0.05, **P<0.01. Scale bars: 0.5 mm (A,C) and 150 μm (B,D).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nf1a^p301/p301; nf1b^p303/p303
Observed In:	lateral larval melanophore stripe lateral larval melanophore stripe melanocyte melanocyte pigment cell development
Stage:	Day 6

Phenotype Detail

Acknowledgments

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