FIGURE

Fig. 6

ID

ZDB-FIG-121210-26

Publication

Shin et al., 2012 - Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

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Fig. 6

nf1a/nf1b mutants demonstrate increased susceptibility to tumorigenesis in a p53 mutant background. (A) Kaplan-Meier tumor-free survival analysis for nf1a^+/-; nf1b^-/-; p53^e7/e7 (n=39) animals demonstrates significantly decreased survival as compared with nf1a^+/+; nf1b^-/-; p53^e7/e7 (n=14) animals (P<0.001). Arrows indicate ages at which animals were identified with brain tumors demonstrating features of diffuse high-grade gliomas. (B,C) 31-week-old nf1a^+/-; nf1b^-/-; p53^e7/e7 animal with a high-grade glioma (B, arrowhead) and 32-week-old nf1a^+/-; nf1b^-/-; p53^e7/e7 animal with a malignant peripheral nerve sheath tumor (MPNST) (C, arrowhead). (D-G) H&E staining of sagittal sections through the high-grade optic glioma (D, boxed area magnified in F) or MPNST (E, boxed area magnified in G). Scale bars: 200 μm (D,E) and 50 μm (F,G).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; nf1a^p301/+; nf1b^p303/p303
Observed In:	optic chiasm glioma trunk nerve sheath tumor
Stage:	Adult

Phenotype Detail

Acknowledgments

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