FIGURE

Fig. 3

ID

ZDB-FIG-121210-23

Publication

Shin et al., 2012 - Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Increased proliferation drives OPC hyperplasia in nf1a^-/-; nf1b^-/- larvae. (A-H) Transverse spinal cord sections of wild-type3 Tg(olig2:GFP) (A-D) and nf1a^-/-; nf1b^-/-; Tg(olig2:GFP) larvae (E-H) labeled with anti-BrdU antibody (B,F, red) or anti-SOX10 antibody (C,G, magenta) at 4 dpf. Arrows indicate BrdU-negative, Tg(olig2:GFP)-, Sox10-positive OPCs. Arrowheads indicate BrdU-positive, Tg(olig2:GFP)-, Sox10-positive OPCs. (I,J) Quantification of total (I) and BrdU-positive OPCs (J) from transverse spinal cord sections of wild-type; Tg(olig2:GFP) and nf1a^-/-; nf1b^-/-; Tg(olig2:GFP) larvae at 4, 5 and 6 dpf. Values indicate mean + s.e.m. per section (n=30 from five each of wild-type and nf1a^-/-; nf1b^-/- larvae). **P<0.01; ***P<0.001. Scale bars: 20 μm.

Expression Data

Genes:	EGFP sox10
Antibody:	Ab1-sox10
Fish:	vu12Tg nf1a^p301/p301; nf1b^p303/p303; vu12Tg
Anatomical Term:	spinal cord glioblast (sensu Vertebrata)
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nf1a^p301/p301; nf1b^p303/p303; vu12Tg
Observed In:	glioblast (sensu Vertebrata) oligodendrocyte progenitor proliferation spinal cord spinal cord glioblast (sensu Vertebrata)
Stage Range:	Day 4 to Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.