FIGURE

Fig. 7

ID

ZDB-FIG-121030-39

Publication

Hinits et al., 2012 - Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation

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Fig. 7

Loss of mef2cb function results in no heart phenotype. In situ mRNA hybridisation for myl7, vmhc and bmp4 (A,B, ventral view, anterior to top) and immunodetection of DM-GRASP (zn5) and Elastin (C, lateral view, anterior to left) of hearts at indicated stage of genotyped mef2cb^fh288mutants and their siblings. A,B. mef2cb^fh288 mutants had a normal looped heart and normal expression of chamber markers, and bmp4 mRNA in OFT (blue arrow), IFT (purple arrow) and AV canal (red arrows). C. Confocal stacks of genotyped mef2cb^fh288 mutants and siblings with a normal looped heart with developed chambers and bulbus arteriosus. Scale=100 μm. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Genes:	bmp4 elna myh7 myl7
Antibodies:	Ab1-elna zn-5
Fish:	WT mef2cb^fh288/fh288
Anatomical Terms:	atrioventricular canal atrium bulbus arteriosus cardiac ventricle sinus venosus
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mef2cb^fh288/fh288
Observed In:	heart looping
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 369(2), Hinits, Y., Pan, L., Walker, C., Dowd, J., Moens, C.B., and Hughes, S.M., Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation, 199-210, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.